Nanotechnologies for Intracellular Protein Delivery: Recent Progress in Inorganic and Organic Nanocarriers

Utilising inorganic nanocarriers for gene delivery.

The delivery of genetic materials into cells to elicit cellular responses has been extensively studied by biomaterials scientists globally. Many materials such as lipids, peptides, viruses, synthetically modified cationic polymers and certain inorganic nanomaterials could be used to complex the negatively charged plasmids and deliver the formed package into cells. The recent literature on the d...

Tatp-mediated intracellular delivery of pharmaceutical nanocarriers.

CPPs (cell-penetrating peptides), including Tatp (transactivator of transcription peptide), have been successfully used for intracellular delivery of a wide variety of cargoes including various nanoparticulate pharmaceutical carriers such as liposomes, micelles and nanoparticles. Here, we will consider the major results obtained in this area with emphasis on Tatp-mediated delivery of liposomes ...

Current Progress of Virus-mimicking Nanocarriers for Drug Delivery

Nanomedicines often involve the use of nanocarriers as a delivery system for drugs or genes for maximizing the therapeutic effect and/or minimizing the adverse effect. From drug administration to therapeutic activity, nanocarriers must evade the host's immune system, specifically and efficiently target and enter the cell, and release their payload into the cell cytoplasm by endosomal escape. Th...

Organic-inorganic mesoporous nanocarriers integrated with biogenic ligands.

Recent Progress and Prospects in Organic Electronics

有機材料は,軽量かつ軟らかく曲げやすいといった 特徴に加え,塗布法や印刷などの低温・簡易プロセス による低価格化への期待が寄せられている.特に,有 機材料を用いた有機電子デバイスの性能向上に伴い, 国内外の研究機関から太陽電池やフレキシブルディス プレイ,電子ペーパー,情報タグ,各種センサなどの研 究が盛んに行われている [1]~[3].例えば,有機エレク トロニクス研究分野では,有機 EL(Electroluminescence)と有機 TFT(Thin-Film Transistor)を用い たフレキシブルディスプレイの実現化をターゲットと して産学連携のもとで研究が推進されている.一方, 実用的有機デバイスの実現のためには,材料,デバイ ス構造,プロセスなどに関して検討を重ねた上で研究 を推進する必要がある.すなわち,有機材料を実用レ ベルのデバイスに応用するには,材料物性の改...